Crystallization process of tricyclic indole derivatives

Crystallization process of tricyclic indole derivatives

  • CN 104,837,489 A
  • Filed: 11/28/2013
  • Published: 08/12/2015
  • Est. Priority Date: 11/30/2012
  • Status: Active Application
First Claim
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1. compositions, its contained I:

  • (I) Wherein;

    R 1for hydrogen, C 1-3alkyl, C 1-3alkoxy or halogen;

    R 2for hydroxyl, halogen, cyano group, C 1-3alkyl, C 1-3alkoxyl, C 1-3fluoroalkyl or C 1-3fluoroalkyloxy;

    R 3for-N-R 7r 8, wherein R 7and R 8for hydrogen, C 1-6alkyl, C 7-10aryl alkyl, or and R 7form nitrogenous C together 4-6aliphatic series ring;

    R 4for O, S, SO, SO 2or CH 2;

    R 5for CH 2, CH 2-CH 2, CH (CH 3)-CH 2or CH 2-CH 2-CH 2;

    R 6for-A 1-R 9, wherein A 1for key or C 1-10alkylidene, and R 9for hydrogen, fluorine or leaving group, or R 9for group-O-R 10, wherein R 10for hydrogen, C 1-3alkyl, C 3-6aryl, C 7-10aryl alkyl or hydroxy-protective group;

    Wherein said compositions comprises the formula II compound being no more than 1%;

    (II) Wherein R 2-R 6as for formula I define.

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