Apparatus and method for producing anti-IgE monoclonal antibodies through online industrially robust regulation of cell states

Apparatus and method for producing anti-IgE monoclonal antibodies through online industrially robust regulation of cell states

  • CN 104,845,880 A
  • Filed: 02/17/2014
  • Published: 08/19/2015
  • Est. Priority Date: 02/17/2014
  • Status: Active Application
First Claim
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1. the device of an on-line industry Robustness regulation and control cell state production anti-IgE Mab, in order to taxis regulation and control cell state, it is characterized in that, this device at least comprises:

  • nutrient solution hold-up vessel, bioreactor can be monitored, harvest product tank, some reason biochemical indicator detectors, online monitoring system, cell state control set for adjusting and linked system, cell retention device, some fluid sterility control speed pushers and some controlled fast pipeline systems, wherein, described nutrient solution hold-up vessel is connected with described bioreactor of monitoring through described fluid sterility control speed pusher by described controlled fast pipeline system, described cell retention device can monitor bioreactor described in connecting, described cell state control set for adjusting and linked system monitor bioreactor through described fluid sterility control speed pusher selectivity with described by described controlled fast pipeline system or described cell retention device is connected, described cell state control set for adjusting and linked system connect described harvest product tank by described controlled fast pipeline system through described fluid sterility control speed pusher, described bioreactor of monitoring connects described online monitoring system by described reason biochemical indicator detector, described online monitoring system is connected with described fluid sterility control speed pusher and sends controls fast instruction to described fluid sterility control speed pusher, above-mentioned all container class devices are all connected by controlled fast pipeline system, wherein, described cell state control set for adjusting and linked system are used for the described regulation and control monitoring different specific cell growth rate and different cell state in bioreactor.

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