Preparation method of otilonium bromide

Preparation method of otilonium bromide

  • CN 105,037,193 A
  • Filed: 08/25/2015
  • Published: 11/11/2015
  • Est. Priority Date: 08/25/2015
  • Status: Active Application
First Claim
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1. a preparation method for otilonium Bromide, is characterized in that, comprises the steps:

  • (1) adjacent octyloxy phenylformic acid in a solvent, and under alkali I effect, react generate mixed acid anhydride with chloro-formic ester, then mixed acid anhydride and para-amino benzoic acid carry out condensation reaction, obtain compound (III);

    Described chloro-formic ester is ClCOOR, R is C 1~ C 4alkyl;

    The structure of described compound (III) is shown below;

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