Bone substitutes grafted by mimetic peptides of human BMP-2 protein

Bone substitutes grafted by mimetic peptides of human BMP-2 protein

  • CN 105,073,150 A
  • Filed: 03/14/2014
  • Published: 11/18/2015
  • Est. Priority Date: 03/14/2013
  • Status: Active Application
First Claim
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1. for the bone alternate material of osseous surgery and tooth operation, it is characterized in that, it comprises:

  • I) there is the solid support be made up of at least one calcium phosphate compound of free hydroxyl group from the teeth outwards, andIi) simulating peptide of a certain amount of people BMP-2 albumen, described simulating peptide has sequenceKIPKACCVPTELSAISMLYL(SEQIDNo.1), or the derivant of a certain amount of described peptide, described simulating peptide or described derivant are and the interactional part of II type BMP cell receptor that described derivant has sequenceKX 1PKX 2Z 1Z 2X 3PTEX 4SAISMLYL (SEQIDNo.3), wherein X 1, X 2, X 3and X 4be identical or different nonpolar amino acid and the Z that may be the same or different 1and Z 2represent cysteine residues or serine residue, the simulating peptide of described a certain amount of BMP-2 albumen is grafted to described hydroxyl by its N-terminal covalent, and the density of described simulating peptide is less than 100 ×

    10 -12mol/mm 2the surface area of described solid support.

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