Preparation method of 6-hydroxy-2,3,5-triamidopyrimidine sulfate

Preparation method of 6-hydroxy-2,3,5-triamidopyrimidine sulfate

  • CN 105,085,411 A
  • Filed: 08/14/2015
  • Published: 11/25/2015
  • Est. Priority Date: 08/14/2015
  • Status: Active Application
First Claim
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1. the preparation method of 6-hydroxyl-2,4, a 5-Triaminopyrimidine vitriol, is characterized in that comprising the following steps:

  • The first step, adds the methanol solution of sodium methylate by Guanidinium nitrate, be heated to boiling, then slowly dropped to by methyl cyanoacetate in above-mentioned solution, generates diamino thing (I);

    Second step, carries out Distillation recovery methyl alcohol by diamino thing (I) solution, then adds water under the environment of 75 DEG C ~ 80 DEG C, stirs clearly molten, acid adding, regulates between pH value to 1 ~ 2, maintains the temperature between 75 DEG C ~ 80 DEG C;

    3rd step, slowly drops to sodium nitrite solution in the vitriol oil, and reaction generates nitrous anhydride gas (II);

    4th step, passes into nitrous anhydride gas (II) and generate nitrous thing (III) in diamino thing (I) solution of second step reaction;

    5th step, is cooled to nitrous thing (III) solution between 20 DEG C ~ 30 DEG C, with water rinse, then joins in hydriding reactor and carry out hydrogenation, generates three ammonia things (IV);

    6th step, generates 6-hydroxyl-2,4,5-Triaminopyrimidine vitriol (V) by three ammonia things (IV) and sulfuric acid reaction.

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