Novel reagent for gene-drug therapy

Novel reagent for gene-drug therapy

  • CN 105,101,951 B
  • Filed: 10/29/2013
  • Issued: 08/03/2021
  • Est. Priority Date: 10/29/2012
  • Status: Active Grant
First Claim
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1. Use of a first agent and a second agent in the preparation of a composition for enhancing intracellular transport of genetic material in a cell transfected with genetic material,wherein the first and second agents are added to the cell simultaneously, separately or sequentially within 1,2, 3, 4 or 5 hours after transfection of the cell with genetic material when the composition is used to enhance intracellular transport of genetic material in the cell after transfection with genetic material,wherein the first agent directs the genetic material away from acidic compartments in the cell, and wherein the second agent stabilizes microtubules and their network,wherein the first agent is complexed DOPE/CHEMS and wherein the second agent is a histone deacetylase inhibitor (HDACi), wherein the HDACi is selected from the group consisting of Tubastatin a, SAHA (vorinostat), trichostatin a.

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