Process for detection of dna modifications and protein binding by single molecule manipulation

Process for detection of dna modifications and protein binding by single molecule manipulation

  • CN 105,122,063 A
  • Filed: 01/22/2014
  • Published: 12/02/2015
  • Est. Priority Date: 01/22/2013
  • Status: Active Application
First Claim
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1. , for determining the method that albumen is combined with the nucleic acid molecules containing nucleotide sequence, described method comprises step:

  • A) by applying physical force to the double chain acid molecule containing nucleotide sequence, described molecule degeneration is made;

    B) described albumen is provided;

    C) described double chain acid molecule renaturation is made when described albumen exists;

    D) blocking-up of double-strandednucleic acid renaturation is detected;

    AndE) position of described blocking-up on described double chain acid molecule is determined.

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