Method for industrially producing butoconazole nitrate intermediate

Method for industrially producing butoconazole nitrate intermediate

  • CN 105,198,708 A
  • Filed: 10/09/2015
  • Published: 12/30/2015
  • Est. Priority Date: 10/09/2015
  • Status: Active Application
First Claim
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1. a method for suitability for industrialized production Nitric acid butoconazole intermediate, is characterized in that, said method comprising the steps of:

  • (1) with magnesium powder and 4-chlorobenzyl chloride be raw material, iodine for catalyzer, in ether, prepare 4-chlorobenzyl chloride Grignard reagent;

    Gained 4-chlorobenzyl chloride Grignard reagent is mixed with the diethyl ether solution of epoxy chloropropane, fully after reaction, obtains reaction solution;

    (2) get step (1) gained reaction solution, under condition of ice bath, slowly drip concentration is the sulfuric acid of 20 ~ 30%, drips to without stopping during solid residue;

    Stratification, abandons aqueous phase, and organic phase is concentrated, rectifying, to obtain final product.

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