Biocompatible hydrogel polymer matrices for cell delivery

Biocompatible hydrogel polymer matrices for cell delivery

  • CN 105,209,016 B
  • Filed: 03/14/2014
  • Issued: 10/30/2020
  • Est. Priority Date: 03/14/2013
  • Status: Active Grant
First Claim
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1. A fully synthetic, polyglycol-based biocompatible biodegradable hydrogel polymer matrix comprising a fully synthetic, polyglycol-based biocompatible hydrogel polymer comprising at least one first monomeric unit bound to at least one second monomeric unit by at least one amide linkage, wherein the polymer forms a matrix that encapsulates:

  • (a) at least one cell or virus; and

    (b) a medium that supports the growth of the at least one cell or virus,wherein the hydrogel polymer is derived from the first monomeric units of 8-arm PEG amine acetate and 8-arm PEG amine and the second monomeric units of 4-arm PEG succinimidyl glutaramide; and

    (c) a phosphate buffer and a viscosity enhancing agent,wherein the fully synthetic, polyglycol-based biocompatible biodegradable hydrogel polymer matrix, when implanted at a target site in an animal body, provides controlled release of the at least one cell or virus to the target site in the animal body via biodegradation of the biocompatible biodegradable hydrogel polymer matrix.

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