METHOD FOR DETECTING INDICATORS FOR DETERMINING DISEASES

METHOD FOR DETECTING INDICATORS FOR DETERMINING DISEASES

  • CN 105,358,978 A
  • Filed: 06/25/2014
  • Published: 02/24/2016
  • Est. Priority Date: 06/26/2013
  • Status: Active Application
First Claim
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1. , for method that is qualitative and/or mensuration disease indicant quantitatively, it is characterized in that, just at least one aggregation type of interior raw misfolded protein matter, preferably at least two kinds of aggregation type research samples, described method comprises the following steps:

  • A) sample to be studied is coated in substrate,B) be added to the probe of detection and mark, it is by marking these aggregations with the specific bond of each self-aggregate, andC) aggregation through mark is detected,Wherein,-step b) can carry out before step is a), and-described disease is selected from by the following group formed;

    Tau pathology, AA-amyloidosis, AL-amyloidosis, AApoAI-amyloidosis, AApoAII-amyloidosis, ATTR-amyloidosis, schizophrenia and other DISC1 pathologies, ALS, frontotemporal lobar degeneration and other FUS-albumen pathologies, diabetes B, Parkinson'"'"'s and other synapse nucleoprotein pathologies, chronic trauma cerebral lesion and other TDP-43-albumen pathology, Huntington disease, familial internal organ amyloidosis and/or Alzheimer disease, and-if A β

    -aggregation detected in the sample to which, so just other these samples of aggregation type research of at least one of interior raw misfolded protein matter.

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