Hydrolyzation purification method for preparing 18F-FDG

Hydrolyzation purification method for preparing 18F-FDG

  • CN 105,646,601 A
  • Filed: 01/21/2016
  • Published: 06/08/2016
  • Est. Priority Date: 01/21/2016
  • Status: Active Application
First Claim
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1. prepare for one kind18The hydrolysising purification method of F-FDG, it is characterised in that:

  • 1) will18By the SPE post (solid-phase extraction column of polymer filler) of polymer filler after F-FTAG dilute with water,18F-FTAG is retained on SPE post;

    2) with 5-60mL water for injection rinsing step (1) the SPE post obtained, and dry up with nitrogen or helium;

    3) step 2 is passed into by the NaOH solution that 1-3mL concentration is 0.5-2M) the SPE post of gained, keep 30-180s;

    4) 5-30mL water for injection rinsing step 3 is used) the SPE post of gained, flow velocity is 0.5-5mL/min, passes sequentially through GraceIC-HSPE post, Waters alkalescence Al2O3SPE post and WatersC18SPE post, collect all liq and be purification18F-FDG�



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