HPLC method for separating and analyzing voriconazole phosphate or related substances of pharmaceutical salts of voriconazole phosphate

HPLC method for separating and analyzing voriconazole phosphate or related substances of pharmaceutical salts of voriconazole phosphate

  • CN 105,699,498 B
  • Filed: 11/25/2014
  • Issued: 06/12/2020
  • Est. Priority Date: 11/25/2014
  • Status: Active Grant
First Claim
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1. An HPLC method for separating and analyzing related substances of voriconazole phosphate or pharmaceutical salts thereof is characterized in that C18, phenyl or cyano silane bonded silica gel is used as a filling agent;

  • the buffer solution and the organic solvent are combined into a mobile phase according to a certain proportion;

    the flow rate is 0.1-1.5 ml/min;

    the column temperature is 0-50 ℃

    ;

    detection wavelength;

    200-400 nm;

    the sample injection volume is 0.1-100 mul;

    elution separation is performed using a gradient or isocratic.

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