Ph-responsive nanometer drug delivery system based on dendrimers modified by short-chain alkane and preparation method and application of drug delivery system

Ph-responsive nanometer drug delivery system based on dendrimers modified by short-chain alkane and preparation method and application of drug delivery system

  • CN 105,748,439 A
  • Filed: 01/29/2016
  • Published: 07/13/2016
  • Est. Priority Date: 01/29/2016
  • Status: Active Application
First Claim
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1. the nanoscale medicine delivery system that the dendrimer modified based on short chain alkanes is self-assembly of, it is characterized in that, the dendrimer modified including aldehyde group modified Natural hydrophilic polysaccharide, short chain alkanes and antineoplastic, the dendrimer that described Natural hydrophilic polysaccharide is modified with short chain alkanes becomes amphiphilic compound by hydrazone key-like, and described amphiphilic compound forms drug-carrying nanometer particle in being formed self-assembly by hydrophobe effect and hydrophobic drug is wrapped in the cavity of self-assembly.

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