Method for purifying N-substitutive derivatives of 1, 2-benzisothiazole quinoline-3-ketone

Method for purifying N-substitutive derivatives of 1, 2-benzisothiazole quinoline-3-ketone

  • CN 105,859,650 A
  • Filed: 05/12/2016
  • Published: 08/17/2016
  • Est. Priority Date: 05/12/2016
  • Status: Active Application
First Claim
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1. a N-substitutive derivative purification process for BIT, comprises the following steps:

  • (1) BIT and alkali metal ion react formation salt, more fragrant with halogenated alkane or substituted benzylRace'"'"'s reaction forms the substituted condensed thing of-N ,-O;

    It is characterized in that;

    (2) aprotic solvent is added in step 1 system, logical anhydrous HCL or anhydrous the HBr ,-N of BITSubstitutive derivative and anhydrous HCL or anhydrous HBr react formation complex salt, separate out crystalline solid, and centrifugal or vacuum filtration separates, driftWash, drain to obtain filter cake;

    (3) step 2 gained filter cake is reacted with aqueous slkali again, separate out free-N substitutive derivative.

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