Sustained-release microgranules, method for preparing same and application of sustained-release microgranules

Sustained-release microgranules, method for preparing same and application of sustained-release microgranules

  • CN 105,878,191 A
  • Filed: 04/26/2016
  • Published: 08/24/2016
  • Est. Priority Date: 04/26/2016
  • Status: Active Application
First Claim
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1. the preparation method of a sustained-release microparticle, it is characterised in that:

  • comprise the following steps;

    1) solid dispersion of water soluble drug and biodegradable and biocompatible slightly water-soluble polymer is prepared;

    2) by step

         1) solid dispersion prepared is dissolved in organic solvent C, forms solid dispersion emulsion, described organic moltenAgent C for can not dissolve described water soluble drug but can dissolve described slightly water-soluble polymer, boiling point less than water and insoluble in or difficultIt is dissolved in the organic solvent of water;

    3) by step

         2) the solid dispersion emulsion that obtains injects in the oil solution containing surfactant and forms uniform emulsion;

    4) volatilized by solvent or solvent extraction make the microgranule in emulsion solidify, collect microgranule, wash for several times with organic solvent D,Again with milli-Q water for several times, to remove the surfactant being attached to microparticle surfaces, then it is dried, it is thus achieved that described slow releaseMicrogranule;

    Wherein, described organic solvent D can not dissolve water soluble drug and slightly water-soluble polymer, and it can mix with described oil solutionMolten, described surfactant there is is good dissolubility simultaneously;

    Described water soluble drug is at least one in protein medicaments, peptide medicament and nucleic acid drug.

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