Multiprotease therapeutics for chronic pain

Multiprotease therapeutics for chronic pain

  • CN 105,916,875 A
  • Filed: 12/19/2014
  • Published: 08/31/2016
  • Est. Priority Date: 12/23/2013
  • Status: Active Application
First Claim
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1. comprising a compositions for clostridial neurotoxin derivant, described clostridial neurotoxin derivant comprises polypeptide,Described polypeptide comprises:

  • A) binding structural domain,B) translocation domain, andC) the first endopeptidase domain of clostridial neurotoxin BoNT/A hypotype it is derived from, andD) the second endopeptidase domain of clostridial neurotoxin BoNT/E hypotype it is derived from;

    Wherein said first endopeptidase domain and described second endopeptidase domain are individually proteolytic activity.

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