Synthetic method of aldehyde dextran, aldehyde dextran-based coating method, and preparation method of microsphere composition

Synthetic method of aldehyde dextran, aldehyde dextran-based coating method, and preparation method of microsphere composition

  • CN 105,949,343 A
  • Filed: 05/04/2016
  • Published: 09/21/2016
  • Est. Priority Date: 05/04/2016
  • Status: Active Grant
First Claim
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1. the synthetic method of an aldehydedodextrans, it is characterised in that comprise the following steps:

  • A, glucosan is dissolved in water after, under inert gas shielding, add EDTA, 1, 4-benzenediol,Sodium borohydride, NaOH and toluene, be stirred at reflux 1-3 hour;

    B, in system drip 2-bromo-1,1-diethoxyethane solution, time for adding be no less than 1 hour;

    After being added dropwise to complete, it is stirred at reflux 12-18 hour;

    C, by the organic phase washed with water in system, obtain aqueous solution, described aqueous solution adds in methanol,Precipitate to hydroformylation sugar precursor;

    D, by described hydroformylation sugar precursor precipitation soluble in water, add toluenesulfonic acid adjust pH to 1-2, add hot waterXie Hou, uses NaOH solution to be adjusted to neutrality, obtains aldehydedodextrans with the form of precipitation.

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