Method for detecting particle dissolution rate

Method for detecting particle dissolution rate

  • CN 106,018,207 A
  • Filed: 08/08/2016
  • Published: 10/12/2016
  • Est. Priority Date: 08/08/2016
  • Status: Active Application
First Claim
Patent Images

1. the detection method of a granule dissolution rate, it is characterised in that concrete detecting step is:

  • 1) prepared by standard substance working solution;

    takeParticle diameter is that the standard substance granule of 0.1~

    1000 micron is placed in transparent vessel, stirs 1~

    20 minute prepared granule after adding solventDispersion liquid, takes particle dispersion immediately to constant volume in volumetric flask, and prepared concentration is the standard substance working solution of 2~

    20mg/mL;

    2) draw standard curve;

    by step

         1) in preparation standard substance working solution join in laser particle analyzer injector, useParticle size distribution detection method detection shading ratio, draws standard curve, obtains standard curve equation;

    3) prepared by product to be tested;

    takeParticle diameter is that the product to be tested granule of 0.1~

    1000 micron is placed in transparent vessel, as step

         1) described in method process afterPrepare particle dispersion, stands 10~

    200 seconds, take particle dispersion to after use solvent dilution constant volume in volumetric flask, by be measuredProduct press step

         2) described method detection shading ratio, the shading of product to be tested is compared step

         2) standard curve drawn, look forGo out the concentration of correspondence, thus quantitatively draw the dissolution rate of granule.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×