Synthetic method of isoborneol formamide compound

Synthetic method of isoborneol formamide compound

  • CN 106,083,633 B
  • Filed: 06/12/2016
  • Issued: 08/24/2021
  • Est. Priority Date: N/A
  • Status: Active Grant
First Claim
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1. A synthetic method of isoborneol formamide compounds is characterized by comprising the following specific steps:

  • (1) adding thionyl chloride into a reactor of a 1, 2-dichloroethane solvent by taking isoborneol formic acid as a raw material, heating and stirring, condensing and refluxing, evaporating the solvent and thionyl chloride after the reaction is finished, and then decompressing and evaporating a target product isoborneol formyl chloride;

    (2) sequentially adding substituted aniline and the isoborneol formyl chloride obtained in the step (1) into a benzene solvent reactor, wherein the molar ratio of the substituted aniline to the isoborneol formyl is 1-1.1;

    1, stirring and refluxing for 4-5h, and tracking the reaction progress by gas phase;

    after the reaction is finished, cooling to separate out a crude product, purifying by using a methanol or ethanol solvent, and drying to obtain the isoborneol formamide compound, wherein the reaction formula is as follows;

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