A kind of antitumor drug ternary conjugate and synthesis and application

A kind of antitumor drug ternary conjugate and synthesis and application

  • CN 106,177,977 A
  • Filed: 07/11/2016
  • Published: 12/07/2016
  • Est. Priority Date: 07/11/2016
  • Status: Active Application
First Claim
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1. an antitumor drug ternary conjugate, it is characterised in that:

  • described ternary conjugate is E-selectin polypeptide ligand-poly-Ethylene glycol-antitumor drug, wherein E-selectin polypeptide ligand be IELLQAR, IDLMQAR, DITWDQLWDLMK,DITWDELWKIMN, RNMSWLELWEHMK or DLWDWVVGKPAG, described antitumor drug includes;

    camptothecine, hydroxy camptothecinOr SN-38, PEG-E select the element conjugate of peptide ligand to include camptothecin medicine with the conjugation sites of camptothecin antineoplastic agents10 of thing or 20 hydroxyls.

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