A kind of method preparing biostromal degraded macromolecular drug release material

A kind of method preparing biostromal degraded macromolecular drug release material

  • CN 106,237,338 A
  • Filed: 09/05/2016
  • Published: 12/21/2016
  • Est. Priority Date: 09/05/2016
  • Status: Active Application
First Claim
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1. the method preparing alternately stratiform Biodegradable high molecular drug release material, it is characterised in that this medicine controlled releasing materialExpect by polymer-based drug loading layer material and polymer-based barrier layer material extruded machine fusion plastification extrusion respectively and convergingStream device exit is superimposed together after the following initiating structure of formation, if then through the dried layer multiplexer that is connected with described junction stationRepeatedly stratiform overlapping effect, formation there is polymer-based drug loading layer and multilamellar knot that polymer-based barrier layer is arranged alternatelyStructure extrudate:

  • (1) macromolecule in polymer-based drug loading layer described in is relatively indissoluble solution or the biodegradated polymer materal of degraded(macromolecule matrix of drug loading layer) and be prone to dissolve or degraded the biodegradated polymer materal (high score of drug loading layerSub-dispersion phase) it is 50~

    99.99%;

    50~

    0.01% blends carrying out mixing by weight percentage;

    (2) the relatively indissoluble solution that the macromolecule in polymer-based barrier layer is melt-processable described in or the macromolecule material of degradedWeight pressed by material (macromolecule matrix of barrier layer) and the macromolecular material (the fractionated polymer dephasing of barrier layer) being prone to dissolve or degradeAmount percentage ratio is 50~

    99.99%;

    50~

    0.01% blends carrying out mixing.

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