Method for synthesizing intermediate of Ilaprazole sodium salt

Method for synthesizing intermediate of Ilaprazole sodium salt

  • CN 106,432,193 A
  • Filed: 06/23/2016
  • Published: 02/22/2017
  • Est. Priority Date: 06/23/2016
  • Status: Active Application
First Claim
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1. a kind of synthetic method of ilaprazole sodium salt intermediate is it is characterised in that comprise the steps:

  • 1) initiation material 5- (1H- pyrroles'"'"'s -1- base) -2-mercaptobenzimidazole is added to equipped with sodium hydroxide solution, deionized waterReaction bulb in, heated and stirred;

    2) add 2- chloromethane oxygen -4- methoxyl group -3- methyl pyridinium chloride, the mixed solution of deionized water, react to terminal, that is,Can get 5- (1H- pyrroles'"'"'s -1- base) -2- [(4- methoxyl group -3- methyl -2- pyridine radicals)-methyl mercapto] -1- hydrogen-benzimidazole.

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