Xuanmai Ganju composition and preparation method thereof

Xuanmai Ganju composition and preparation method thereof

  • CN 106,511,745 B
  • Filed: 11/25/2016
  • Issued: 06/16/2020
  • Est. Priority Date: 11/25/2016
  • Status: Active Grant
First Claim
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1. A preparation method of a medicine composition for treating fire excess from yin deficiency, upward floating of deficient fire, dry mouth and nose and sore throat is disclosed, wherein the composition is prepared from the following traditional Chinese medicine raw materials in parts by weight:

  • 10 parts of radix scrophulariae, 10 parts of radix ophiopogonis, 10 parts of liquorice, 10 parts of platycodon grandiflorum and 10 parts of radix scrophulariaeThe preparation method of the composition is characterized by comprising the following steps;

    preparing a radix scrophulariae extract;

    taking a figwort root medicinal material, adding 6-10 times of water in parts by weight of the figwort root medicinal material, and extracting for 1-3 times, wherein each time lasts for 2-4 hours;

    filtering the extracting solution, concentrating until the relative density is 1.05-1.10 at the temperature of 60 ℃

    , adding ethanol to ensure that the final concentration of the ethanol is 60-80%, refrigerating, filtering, concentrating the filtrate until the relative density is 1.10-1.15 at the temperature of 60 ℃

    , injecting the obtained concentrate into a macroporous adsorption resin column, eluting by using purified water with the volume of 8-12 times of the column volume, eluting by using ethanol with the volume of 6-8 times of the column volume being 20-30%, collecting 20-30% of eluent, and concentrating the obtained eluent to obtain a radix scrophulariae extract;

    preparing the ophiopogon root and liquorice extract;

    taking radix ophiopogonis and liquorice, adding 20-30% ethanol solution which is 6-10 times of the weight of the radix ophiopogonis and the liquorice, and extracting for 1-4 times, wherein each time lasts for 2-4 hours;

    filtering and concentrating the extracting solution, concentrating the extracting solution until the relative density is 1.05-1.10 at the temperature of 60 ℃

    , adding ethanol to ensure that the final concentration of the ethanol is 60-80%, refrigerating and filtering the extracting solution, concentrating the filtrate until the relative density is 1.10-1.15 at the temperature of 60 ℃

    , injecting the obtained concentrate into a macroporous adsorption resin column, eluting the concentrate by using purified water with 6-10 times of column volume, then eluting by using 10-20% ethanol with 6-8 times of column volume, then eluting by using 30-50% ethanol with 4-6 times of column volume, collecting 30-50% eluent, and concentrating the obtained eluent to obtain the ophiopogon root and licorice extract;

    preparing a platycodon extract;

    adding 6-10 times of 40-60% ethanol solution into the platycodon grandiflorum medicinal material, and extracting for 1-4 times for 1-3 hours each time;

    filtering and concentrating the extracting solution until the relative density is 1.10-1.15 at the temperature of 60 ℃

    , injecting the obtained concentrate into a macroporous adsorption resin column, eluting by using purified water with 6-10 times of the column volume, then eluting by using 10-20% ethanol with 6-8 times of the column volume, then eluting by using 50-70% ethanol with 6-8 times of the column volume, collecting 50-70% eluent, and concentrating the obtained eluent to obtain a platycodon extract;

    wherein, the preparation of the figwort root extract, the preparation of the ophiopogon root and liquorice root extract and the preparation of the platycodon root extract use macroporous absorption resin D101;

    the preparation method of the medicine is that the Xuanmai Ganju extract and the pharmaceutic adjuvant are mixed together and prepared into the medicine preparation composition according to the conventional method.

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