Extraction and separation method of compound and application

Extraction and separation method of compound and application

  • CN 106,565,525 A
  • Filed: 11/02/2016
  • Published: 04/19/2017
  • Est. Priority Date: 11/02/2016
  • Status: Active Application
First Claim
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1. a kind of extraction of compound and separation method, it is characterised in that comprise the following steps:

  • Step 1, vegetable material pretreatmentThe Pericarpium Zanthoxyli for collecting lucifuge indoors, ventilation, dries in the shade, by dry Pericarpium Zanthoxyli destemming remove seed remove impurity after, in constant temperature blast drying ovenIn in 50 DEG C place drying 8h, then Pericarpium Zanthoxyli fruit peel powder is broken to 40 mesh;

    Step 2, extract by solvents Pericarpium ZanthoxyliWeigh 5g Pricklyash peels, 95% ethanol of selection is Extraction solvent, solid-liquid ratio 1:

    10 extract, and concrete grammar is:

    With 95%EtOH solution extracts 48h, is filtered to remove Pericarpium Zanthoxyli residue, is evaporated, uses MeOH:

    Petroleum ether=1:

    1 extraction, collectsMeOH phases, then pH is adjusted to into 2~

    3 by solution HCl solution, stand overnight, then adjust pH to 9~

    10 with NaOH, stand overnight,With isopyknic CHCl3Extraction three times, collects CHCl3Phase, is evaporated standby, extraction three times altogether, merges the extracting solution of three times, decompressionDistillation, by extract obtained vacuum drying, obtains Pericarpium Zanthoxyli crude extract;

    Pretreatment is carried out afterwards, obtains Pericarpium Zanthoxyli crude extract 73g.

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