Preparation method of tenofovir alafenamide

Preparation method of tenofovir alafenamide

  • CN 106,632,484 B
  • Filed: 01/05/2017
  • Issued: 06/12/2020
  • Est. Priority Date: 01/05/2017
  • Status: Active Grant
First Claim
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1. A preparation method of tenofovir alafenamide is characterized by comprising the following specific steps:

  • (1) heating PMPA to react with a chlorination reagent to obtain PMPA-2 Cl;

    the chemical reaction formula is as follows;

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