System and method for ionization

System and method for ionization

  • CN 106,683,972 B
  • Filed: 11/09/2016
  • Issued: 11/24/2020
  • Est. Priority Date: 11/09/2015
  • Status: Active Grant
First Claim
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1. A system for analyzing a sample, comprising:

  • an electrospray source configured toDirecting a first portion of the liquid flow from the chromatography apparatus to a pressurized waste reservoir via a waste outlet;

    directing a second portion of the liquid flow to an electrospray ionization outlet to form a spray, a flow rate of the second portion of the liquid flow determined by a pressure of the pressurized waste reservoir and a pressure of the pressurized waste container held fixed at a value between 2psi and 50psi, whereby a relationship between the flow rate of the second portion of the liquid flow and the pressure of the pressurized waste reservoir is the same across a liquid chromatography flow range; and

    isCharging and desolvating the spray to form ions of constituents of the sample; and

    a mass resolving device configured to;

    receiving the ions; and

    isCharacterizing the mass-to-charge ratio of the ions.

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