3 (1 (aminopyridine epoxide) ethyl) heterocyclic carbamate derivatives and its synthetic method and application

3 (1 (aminopyridine epoxide) ethyl) heterocyclic carbamate derivatives and its synthetic method and application

  • CN 106,866,627 A
  • Filed: 01/24/2017
  • Published: 06/20/2017
  • Est. Priority Date: 01/24/2017
  • Status: Active Grant
First Claim
Patent Images

1. there is the compound of structure shown in formula I or its pharmaceutically acceptable salt, hydrate, solvate, polymorph, mutuallyTautomeric or prodrug, it is characterised in that:

  • In formula,R1Selected from H, CN, C1-6Alkyl, C3-6Cycloalkyl, C2-6Alkenyl, C2-6Alkynyl, C6Aryl, C5-6Heteroaryl, C3-6Heteroalicyclyl,C6Aromatic ring and heterocyclic radical, and R1In each hydrogen atom can be by R3Substitution;

    R2ForR3Selected from H, CF3

    C1-6Alkyl, C3-6Cycloalkyl, C2-6Alkenyl, C2-6Alkynyl, C6Aryl, C5-6Heteroaryl, C3-6Heterolipid ringBase, C1-6Alkoxy, C3-6Cycloalkyloxy, C6Aryloxy group, C5-6Heteroaryloxy, C3-6Heterolipid epoxy radicals, C1-6Alkylamino, C3-6CycloalkanesAmino, C6Fragrant amino, C5-6Heteroaryl amino, C3-6Heterolipid ring amino;

    R4

    R5

    R6Selected from H, halogen, CN, NO2

    NH2

    N(CH3)2

    NHCH3

    OH、

    OCH3

    OC2H5

    OCF3

    CF3, cyclopropyl, C1-6Alkyl, sulfonyl, Sulfonylalkyl.

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