A kind of antibacterial nanofiber membrane and preparation method thereof

A kind of antibacterial nanofiber membrane and preparation method thereof

  • CN 108,251,965 A
  • Filed: 02/05/2018
  • Published: 07/06/2018
  • Est. Priority Date: 02/05/2018
  • Status: Active Application
First Claim
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1. a kind of preparation method of antibacterial nanofiber membrane, which is characterized in that the method includes:

  • Chitosan after purification is dissolved in the mixed solvent of 3% acetic acid and dimethyl sulfoxide, and magnetic agitation is used at a temperature of 30 DEG CDevice carries out dissolving 12h, obtain for a concentration of 3.0% spinning solution, then to the spinning solution carry out electrostatic spinning process, obtainAvarage fiber diameter is the chitosan nano fiber membrane of 188 ±

    62nm, and the technological parameter of the electrostatic spinning process includes:

    SpinningVoltage is 16kV, receives distance as 150mm, and spinning rate is 0.6mL/h;

    By the chitosan nano fiber membrane with after glutaraldehyde vapor crosslinking 12h, it is put into hothouse and is dried in vacuo, then putEnter culture dish;

    5mL copper-baths, 2.5mL sodium hydroxide solutions, 5 ~ 10mL vitamin c solutions are added sequentially to be placed with the shellIn the culture dish of glycan nano fibrous membrane, and obtained after standing preset duration containing nano cuprous oxide under preset temperatureChitosan nano fiber membrane;

    The chitosan nano fiber membrane containing nano cuprous oxide is taken out from the culture dish, is washed with deionized water,And be put into hothouse and be dried in vacuo, obtain antibacterial nanofiber membrane.

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