Separation of Amlodipine antimer

Separation of Amlodipine antimer

CN
  • CN 1,100,038 C
  • Filed: 02/21/2000
  • Issued: 01/29/2003
  • Est. Priority Date: 02/21/2000
  • Status: Active Grant
First Claim
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1. the method for (R)-(+) that from mixture, isolates amlodipine-and (S)-(-)-isomer.It is characterized in that:

  • comprise following reaction, promptly at chiral auxiliary(reagent) hexadeuterated dimethyl sulfoxide (DMSO-d 6) or contain DMSO-d 6Organic solvent in, mixture of isomers is with resolving chiral reagent D-or L-tartrate reaction, in conjunction with a DMSO-d 6The D-tartrate of (S)-(-)-amlodipine, or in conjunction with a DMSO-d 6(R)-(+)-amlodipine the L-tartrate and respectively the precipitation, wherein amlodipine and tartaric mol ratio approximate 0.25.

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