Oil in water emulsions containing 2, 6 -diisopropyl phenic and ehtylenedinamine-tetra acetic salt

Oil in water emulsions containing 2, 6 -diisopropyl phenic and ehtylenedinamine-tetra acetic salt

  • CN 1,106,192 C
  • Filed: 03/17/1995
  • Issued: 04/23/2003
  • Est. Priority Date: 03/17/1995
  • Status: Active Grant
First Claim
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1. aseptic medicinal composition that is used for parenteral, comprise a kind of emulsion oil-in-water, in emulsion, be dissolved in the propofol water emulsifying in a kind of and the immiscible solvent of water, and it is stable with a kind of surfactant, said composition also contains the edetate of some, and wherein as many as 10 is taking place the quantity of edetate 3After the pollution of bacterium colony generation unit (in 20~

  • 25 ℃

    temperature range), enough stop the clinical relevant growth of microorganism that is selected from kinds such as staphylococcus aureus, escherichia coli, white candida mycoderma and Pseudomonas aeruginosa in 24 hours, to be no more than more than 10 times at least by test determination, in test, in 20-25 ℃

    temperature range, add to the flushing suspension of every kind of microorganism in the aliquot of described compositions, every approximately ml 50 bacterium colonies of its amount generate unit, and described aliquot is cultivated in 20-25 ℃ and

    the later check count plate at 24 hours.

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