Subsitutted 2(2,6-dioxopiperidin-3-yl) phthalimides and -1-xoisoindolines and method of reducing TNF-alpha levels

Subsitutted 2(2,6-dioxopiperidin-3-yl) phthalimides and -1-xoisoindolines and method of reducing TNF-alpha levels

CN
  • CN 1,117,089 C
  • Filed: 07/24/1997
  • Issued: 08/06/2003
  • Est. Priority Date: 07/24/1996
  • Status: Active Grant
First Claim
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1. compound that is selected from the group that following material forms:

  • (a) (the R)-enantiomer of the chiral purity basically of the dioxopiperidin of 2.6-shown in the following formula, (the S)-enantiomer of chiral purity basically, or (R)-and (S)-mixture of enantiomer;

    Wherein;

    One is C=O among X and the Y, and another is C=O or CH among X and the Y 2;

    (i) R 1, R 2, R 3And R 4Be the alkyl of halogen, a 1-4 carbon atom or the alkoxyl group of 1-4 carbon atom independently of one another, or (ii) R 1, R 2, R 3And R 4One of be-NHR 5, remaining R 1, R 2, R 3And R 4Be hydrogen;

    R 5Be hydrogen, R 6Alkyl, benzyl or halogen for 1-8 carbon atom;

    Perhaps R 5Be the alkyl of 1-8 carbon atom, R 6Be alkyl, benzyl or the halogen of hydrogen, a 1-8 carbon atom;

    (b) described 2, the acid salt of 6-dioxopiperidin.

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