Process for diastereoselective synthesis of nucleoside analogues

Process for diastereoselective synthesis of nucleoside analogues

  • CN 1,149,871 A
  • Filed: 04/21/1995
  • Published: 05/14/1997
  • Est. Priority Date: 04/23/1994
  • Status: Abandoned Application
First Claim
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1. the three-dimensional system of selection of a preparation formula (1) compound:

  • Wherein, W is S, S=O, SO 2, or O;

    X is S, S=O, SO 2, or O;

    R 1Be hydrogen or acyl group;

    And R 2Be purine or pyrimidine base or their analogue or derivative;

    This method comprises the step that makes purine or pyrimidine base or their analogue and formula (IVa) or the reaction of intermediate (IVb);

    R wherein 3Be carbonyl or the carbonyl derivative that replaces;

    Represent halogen, cyano group or R with G 5SO 2-, R wherein 5The alkyl that expression is at random replaced by one or more halogens, or the phenyl that replaces arbitrarily;

    It is characterized in that the reaction with purine or pyrimidine base or their analogue is to carry out under the situation of not adding lewis acid catalyst.

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