Method for preparing 4-acetoxy-2 'alpha'-benzoyloxy-5 'beta', 20-epoxy-1,7 'beta', 10 'beta'-trihydroxy-9-oxo-tax-11-en-13 'alpha'-yl(2R, 3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tr

Method for preparing 4-acetoxy-2 'alpha'-benzoyloxy-5 'beta', 20-epoxy-1,7 'beta', 10 'beta'-trihydroxy-9-oxo-tax-11-en-13 'alpha'-yl(2R, 3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate tr

CN
  • CN 1,151,741 A
  • Filed: 07/07/1995
  • Published: 06/11/1997
  • Est. Priority Date: 07/08/1994
  • Status: Abandoned Application
First Claim
Patent Images

1. (2R, 3S)-3-t-butoxycarbonyl amino-2-hydroxyl-3-phenylpropionic acid 4-acetoxyl-2 α

  • -benzoyloxy-5 β

    , 20-epoxy-1,7 β

    , the preparation method of the trihydrate of 10 β

    -trihydroxy--9-oxygen-Japanese yew-11-alkene-13 α

    -ester is characterized in that making (2R, 3S)-3-t-butoxycarbonyl amino-2-hydroxyl-3-phenylpropionic acid 4-acetoxyl-2 α

    -benzoyloxy-5 β

    , 20-epoxy-1,7 β

    , 10 β

    -trihydroxy--9-oxygen--Japanese yew-11-alkene-13 α

    -ester is in water/C 1-3Crystallization in the fatty alcohol mixture, the dry product that obtains under the condition of determining by temperature, pressure and humidity subsequently.

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