Compounds and methods for immunotherapy and diagnosis of tuberculosis

Compounds and methods for immunotherapy and diagnosis of tuberculosis

CN
  • CN 1,200,147 A
  • Filed: 08/30/1996
  • Published: 11/25/1998
  • Est. Priority Date: 09/01/1995
  • Status: Abandoned Application
First Claim
Patent Images

1. a peptide species, this polypeptide comprises the solubility antigen of mycobacterium tuberculosis or only in the conservative immunogenicity part that replaces and/or modify this different antigenic variants, wherein said antigen has the N terminal sequence of the group of being selected from down:

  • (a) Asp-Pro-Val-Asp-Ala-Val-Ile-Asn-Thr-Thr-Cys-Asn-Tyr-Gly-Gln-Val-Val-Ala-Ala-Leu;

    (SEQ ID NO.120) be (c) Ala-Ala-Met-Lys-Pro-Arg-Thr-Gly-Asp-Gly-Pro-Leu-Glu-Ala-Ala-Lys-Glu-Gly-Arg of Ala-Val-Glu-Ser-Gly-Met-Leu-Ala-Leu-Gly-Thr-Pro-Ala-Pro-Ser (SEQ ID NO.121) (b);

    (SEQ ID NO.122) be Tyr-Tyr-Trp-Cys-Pro-Gly-Gln-Pro-Phe-Asp-Pro-Ala-Trp-Gly-Pro (d);

    (SEQ ID NO.123) be Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp-Gln-Gln-Xaa-Ala-Val (e);

    (SEQ ID NO.124) be Ala-Glu-Glu-Ser-Ile-Ser-Thr-Xaa-Glu-Xaa-Ile-Val-Pro (f);

    (SEQ ID NO.125) be Asp-Pro-Glu-Pro-Ala-Pro-Pro-Val-Pro-Thr-Thr-Ala-Ala-Ser-Pro-Pro-Ser (g);

    (SEQ ID NO.126) be Ala-Pro-Lys-Thr-Tyr-Xaa-Glu-Glu-Leu-Lys-Gly-Thr-Asp-Thr-Gly (h);

    (SEQ ID NO.127) be Asp-Pro-Ala-Ser-Ala-Pro-Asp-Val-Pro-Thr-Ala-Ala-Gln-Leu-Thr-Ser-Leu-Leu-Asn-Ser-Leu-Ala-Asp-Pro-Asn-Val-Ser-Phe-Ala-Asn (i);

    (SEQ ID NO.128) and (j) Ala-Pro-Glu-Ser-Gly-Ala-Gly-Leu-Gly-Gly-Thr-Val-Gln-Ala-Gly;

    (SEQ ID NO.136) wherein Xaa can be any amino acid.

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