Method of managing chemotherapy of patients who are HIV positive based on phenotypic drug sensitivity of human HIV strains

Method of managing chemotherapy of patients who are HIV positive based on phenotypic drug sensitivity of human HIV strains

  • CN 1,209,875 A
  • Filed: 01/24/1997
  • Published: 03/03/1999
  • Est. Priority Date: 01/26/1996
  • Status: Abandoned Application
First Claim
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1. method of controlling HIV positive patients HIV chemotherapy, comprise the clone that HIV is infected sensitivity with a HIV-DNA construct transfection that comes the sequence of the HIV pol gene that obtains since patient and lacked this sequence, cultivate described cells transfected to produce the original seed of embedded virus, estimate described embedded virus and specify a value to the phenotype susceptibility of the inhibitor of the described enzyme of HIV pol gene code and to it, structure contains the data set of the analog value of described embedded virus sensitivity value and the chimeric wild-type strain of HIV, thereby repeat at least two other sensitivity assessments of inhibitor and make up at least three these data sets altogether, represent that with two dimension or three-dimensional diagram form this data set makes the difference between the mosaic type and wild type susceptibility in each data set that the naked eyes measured value of the resistance that chimeric original seed handles described inhibitor is provided, and select the optimal inhibition agent according to measured resistance diagram.

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