Potassium sodium dehydroandroandrographolide succinates and their preparations

Potassium sodium dehydroandroandrographolide succinates and their preparations

  • CN 1,223,589 C
  • Filed: 02/06/2004
  • Issued: 10/19/2005
  • Est. Priority Date: 02/06/2004
  • Status: Active Grant
First Claim
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1. , a kind ofly contains 14-dehydrogenation-11,12-two dehydrogenation rographolides-3, the pharmaceutical composition of 19-disuccinic acid half ester k-na salt, it is freeze-dried powder injection, it is characterized in that, described lyophilized injectable powder, per 1000 bottles of 14-dehydrogenations-11 that contain 200g, 12-two dehydrogenation rographolides-3,19-disuccinic acid half ester k-na salt, per 1000 bottles of lyophilized injectable powders are prepared by following method:

  • the 14-dehydrogenation-11 of getting 200g, 12-two dehydrogenation rographolides-3,19-disuccinic acid half ester k-na salt adds the dissolving of 500ml 80% cumulative volume water for injection, surveys pH, the NaHCO with 4% 3Solution is regulated PH to 6.5~

    7.5, adds to the full amount of water for injection, and adds the carbon removal of activated carbon decolorizing after-filtration, surveys PH, content, qualified after, sterile filtration, after clarity was qualified, can became 1000 bottles, half tamponade, the inlet lyophilize, outlet, gland rolls lid, lamp inspection, packing.

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