Nucleotide analogs

Nucleotide analogs

CN
  • CN 1,244,200 A
  • Filed: 07/25/1997
  • Published: 02/09/2000
  • Est. Priority Date: 07/26/1996
  • Status: Abandoned Application
First Claim
Patent Images

1. the compound of following formula (1a) and salt, hydrate, tautomer and solvate:

  • Wherein Z is-OC (R independently 2) 2OC (O) X (R) a, ester, acid amides or-H, but at least one Z is-OC (R 2) 2OC (O) X (R) aA is antiviral phosphono methoxyl nucleotide analogue thing residue;

    X is N or O;

    R 2Be independently-H, unsubstituted or by 1 or 2 halogen, cyano group, azido-, nitro or OR 3The C that replaces 1-C 12Alkyl, C 5-C 12Aryl, C 2-C 12Alkenyl, C 2-C 12Alkynyl group, C 7-C 12Alkenyl aryl, C 7-C 12Alkynyl group aryl or C 6-C 12Alkylaryl, wherein R 3Be C 1-C 12Alkyl, C 2-C 12Alkenyl, C 2-C 12Alkynyl group or C 5-C 12Aryl;

    R is independently-H, unsubstituted or by 1 or 2 halogen, azido-, nitro ,-N (R 4) 2-or OR 3The C that replaces 1-C 12Alkyl, C 5-C 12Aryl, C 2-C 12Alkenyl, C 2-C 12Alkynyl group, C 7-C 12Alkenyl aryl, C 7-C 12Alkynyl group aryl or C 6-C 12Alkylaryl, wherein R 4Be independently-H or C 1-C 8Alkyl;

    Condition is;

    at least one R is not H;

    When X was O, a was 1, and perhaps when X was N, a was 1 or 2;

    Condition is;

    when a is 2 and X when being N, (a) two R groups that connect with the N atom can form a carbocyclic ring or oxygen containing heterocycle, and (b) a R group that is connected with the N atom can also be OR 3Perhaps (c) two R groups that are connected with the N atom can be-H.

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