4-aminoalkoxy-1H-benzimidazole derivatives, their preparation and their use as dopamine autoreceptor D2 agonists

4-aminoalkoxy-1H-benzimidazole derivatives, their preparation and their use as dopamine autoreceptor D2 agonists

  • CN 1,252,793 A
  • Filed: 01/13/1998
  • Published: 05/10/2000
  • Est. Priority Date: 02/18/1997
  • Status: Abandoned Application
First Claim
Patent Images

1. formula (I) compound or its pharmacy acceptable salt:

  • Wherein;

    R 1For hydrogen, trifluoromethyl, pentafluoroethyl group, seven fluoropropyls, have the straight or branched alkyl of 6 carbon of as many as or optional be selected from the benzyl that following substituting group replaces by 1-3;

    halogen atom, amino, nitro, hydroxyl, C 1-C 6Alkoxyl group;

    R 2Be hydrogen or C 1-C 6Alkyl;

    R 3For hydrogen, straight or branched alkyl, cyclohexyl methyl with 10 carbon atoms of as many as ,-(CH 2) mAr, wherein Ar is phenyl, thienyl, furyl or pyridyl, they each optionally be selected from following substituting group by one to two and replace;

    halogen atom, C 1-C 6Alkoxyl group, trifluoromethyl or C 1-C 6Alkyl;

    Perhaps NR 2R 3Be 1,2,3,4-tetrahydroquinoline-1-base or 1,2,3,4-tetrahydroisoquinoline-2-base;

    Y is halogen atom, low alkyl group, amino and lower alkoxy;

    N is 1-5.

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