Method for preparing medicine composition capable of inhibiting post infective virus proteinase

Method for preparing medicine composition capable of inhibiting post infective virus proteinase

  • CN 1,253,019 A
  • Filed: 09/10/1999
  • Published: 05/17/2000
  • Est. Priority Date: 09/28/1989
  • Status: Abandoned Application
First Claim
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1. One kind prepare comprise shown in the formula (I), the effective method of the pharmaceutical composition of diamino compounds or its physiologically acceptable salt on the therapeutics, Wherein Y is oxygen or sulfur, L be 0 and m be 1A is a formula (IV) group, A *Be a formula (IV *) group, D-(E) n-(F) o-(G) p- (IV) D *-(E *) N*-(F *) O*-(G *) P*-(IV *) wherein, N, n *, o, o *, p and p *Represent integer 0 or 1 independently of one another, E, E *, F, F *, G and G *Represent an amino acid residue independently of one another, said aminoacid is selected from ALa, Arg, Asp, Asn, Cpg, Cbg, Glu, Gly, ILe, Leu, Lys, Met, Nva, Phe, Ser, Tbg, Trp, Tyr and Val, D is R 1Formula V or (VI) shown in a group, D *Be R 1*Or formula (V *) or (VI *) shown in a group, Wherein,R 1And R 1*Represent (a C independently 1-C 6) alkyl sulphonyl, R 12R 13N-CO-or Het-(C 1-C 6) alkyl-O-CO-;

  • R wherein 12Represent (a C 1-C 6) alkyl and R 13Represent Het-(C 1-C 4) alkyl, wherein Het is thiazolyl, isothiazolyl, tetrazole radical, pyridine radicals, pyrazolyl, pyrimidine radicals, indyl, isoindolyl, thienyl, imidazole radicals, piperidyl, furyl glycosyl, chinol base, indazolyl, 2,3-phthalazinyl, quinolyl, isoquinolyl, quinoxalinyl, quinazolyl or cinnolines base, and Het can be by (C 1-C 4) alkyl replacement one or many;

    And R 9And R 9*Represent (a C 1-C 10) alkyl, cyclohexyl methyl, benzyl, 2-phenylethyl, 1-naphthyl methyl, 2-naphthyl methyl, 4-methyl-benzyl, 4-methoxy-benzyl or 4-benzyl chloride base;

    And R 2And R 2*Represent a n-pro-pyl, normal-butyl, isobutyl group, n-pentyl, n-hexyl, cyclohexyl methyl, benzyl, 4-methyl-benzyl, 4-methoxy-benzyl, 3,4-methylenedioxy benzyl or 4-benzyl chloride base;

    And R 3, R 3*, R 4, R 4*, R 6And R 6*Be a H;

    R 5And R 5*Be a H or OH independently;

    It is characterized in that, make the pharmacology go up at least a formula (I) chemical compound of effective dose or its physiologically acceptable salt and one or more pharmaceutical carriers in case of necessity and make the suitable dosage form of using.

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