1,4-dichloropyridine-3,5-carboxylic-acid derivatives and preparation method thereof

1,4-dichloropyridine-3,5-carboxylic-acid derivatives and preparation method thereof

  • CN 1,269,362 A
  • Filed: 12/30/1999
  • Published: 10/11/2000
  • Est. Priority Date: 12/05/1994
  • Status: Abandoned Application
First Claim
Patent Images

1. General formula (IVa) and (IVb) shown in 1, the 4-dihydropyridine compounds R wherein 1The alkyl that contains 8 carbon atoms at the most of expression straight or branched, this alkyl randomly has the alkoxyl group that contains 6 carbon atoms at the most or the hydroxyl substituent of straight or branched, or represents to contain the cycloalkyl of 3-7 carbon atom, R 2Expression R wherein 4And R 5Identical or different, expression halogen, cyano group, ethynyl, trifluoromethoxy, methylthio group, nitro, trifluoromethyl or contain the straight or branched alkyl of 4 carbon atoms at the most, alkenyl, alkynyl or alkoxyl group, and R 4And R 5One of randomly represent hydrogen, A represents the alkyl that contains 8 carbon atoms at the most of hydrogen or straight or branched, or expression is by phaseWith or different following substituting group randomly trisubstd phenyl or benzyl at the most, instituteStating substituting group is hydroxyl, nitro, halogen, cyano group, carboxyl, trifluoromethyl, threeThe fluorine methoxyl group, contain the straight or branched alkoxyl group of 6 carbon atoms, perhaps table at the mostShow by formula-NR 6R 7Or-SO 2R 8Shown in optional phenyl or the benzyl that replaces of group, R wherein 6And R 7Identical or different, and expression hydrogen, phenyl or straight or branched are extremely The alkyl that contains 5 carbon atoms more, R 8The expression straight or branched to contain 4 carbon at the most former The alkyl or phenyl of son.

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