Condensation, phospholipids compounds and their derivs, prepared by said condensation

Condensation, phospholipids compounds and their derivs, prepared by said condensation

  • CN 1,306,963 A
  • Filed: 01/28/2000
  • Published: 08/08/2001
  • Est. Priority Date: 01/28/2000
  • Status: Abandoned Application
First Claim
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1. , a kind of condensation reaction and with the phospholipids compounds and the derivative thereof of this condensation reaction preparation.It is characterized in that:

  • this condensation reaction is made up of following three steps;

         1) with reactant (1), reactant (2) and TPS by mol wt than 1.0;

    (1.0-4.0);

    (1.0-5.0) join in three mouthfuls of round-bottomed flasks, add a certain amount of pyridine again or other solvent dissolves it, heating, controlled temperature stirred 1-36 hour at 40-100 ℃

    ;

    Reaction formula is as follows;

    Reactant (1) reactant (2) is annotated;

    TPS=2,4,6-Triisopropylbenzenesulfonyl chlorideIn the formula;

    1. R 1=R 2Or R 1

    R 22. R 1And R 2All any group, atom or molecule;

    3. work as R 1During=H, reactant 1 can become chain again and replace phosphoric acid salt;

    4. M can be a kind of metal in following, M=Li, and Na, K, Ca, Mg, Ba;

    5. X=-OH ,-NH 2,-SH or any group that contains reactive hydrogen;

    6. R 3Can be any atom, group or molecule;

    2) reaction is finished, and steams and removes all solvents, obtains solids, and this material obtains crude product with ether or other suitable solvent extraction with the extracting solution evaporate to dryness;

    3) crude product carries out separation and purification with silicagel column or other suitable stopping composition pillar, with the appropriate solvent flushing, collects product.Productive rate can reach more than 92%, also can adopt recrystallization method to carry out purifying.

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