Inhibitors of glycogen synthase kinase 3

Inhibitors of glycogen synthase kinase 3

  • CN 1,312,807 A
  • Filed: 06/18/1999
  • Published: 09/12/2001
  • Est. Priority Date: 06/19/1998
  • Status: Abandoned Application
First Claim
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1. a compound is characterized in that, this compound has structure:

  • Wherein;

    W can choose substituted carbon or nitrogen wantonly;

    X and Y are selected from nitrogen, oxygen respectively and can choose the carbon of replacement wantonly;

    A is aryl and the heteroaryl that can choose replacement wantonly;

    R 1, R 2, R 3And R 4Be selected from hydrogen, hydroxyl respectively and can choose low alkyl group, cyclic low-grade alkyl, alkylamino alkyl, lower alkoxy, amino, alkylamino, alkyl-carbonyl, aryl carbonyl, aromatic alkyl carbonyl, heteroaryl carbonyl, heteroaralkyl carbonyl, aryl and the heteroaryl of replacement wantonly, and R 1'"'"', R 2'"'"', R 3'"'"' and R 4'"'"' be selected from hydrogen respectively and can choose the low alkyl group of replacement wantonly;

    R 5And R 7Be selected from hydrogen, halogen respectively and can choose the inferior amido of low alkyl group, cycloalkyl, alkoxyl group, amino, aminoalkoxy, alkylamino, aryl alkyl amino, heteroaralkyl amino, arylamino, heteroaryl amino, ring, the inferior amido of heterocycle, amidino groups, ring amidino groups, heterocycle amidino groups, guanidine radicals, aryl, dibenzyl, heteroaryl, heterobiaryl, Heterocyclylalkyl and the aromatic yl sodium sulfonamido of replacement wantonly;

    R 6Be selected from hydrogen, hydroxyl, halogen, carboxyl, nitro, amino, amido, amidino groups, imino-, cyano group and replacement or unsubstituted low alkyl group, lower alkoxy, alkyl-carbonyl, aryl carbonyl, aromatic alkyl carbonyl, the heteroaryl carbonyl, the heteroaralkyl carbonyl, alkyl carbonyl oxy, aryl-carbonyl oxygen, aralkyl carbonyl oxygen base, alkyl amino carbonyl oxy, arylamino carbonyl oxygen base, formyl radical, lower alkylcarbonyl, elementary alkoxy carbonyl, aminocarboxyl, aminoaryl, alkyl sulphonyl, sulfonamido, aminoalkoxy, alkylamino, heteroaryl amino, alkyl-carbonyl-amino, alkyl amino-carbonyl amino, aromatic yl aminocarbonyl amino, aromatic alkyl carbonyl amino, the heteroaralkyl carbonylamino, aryl-amino-carbonyl, the heteroaryl carbonylamino, the cyclic amide base, epithio is for amido, the ring amidino groups, the heterocycle amidino groups, cyclo-imino, the heterocycle imino-, guanidine radicals, aryl, heteroaryl, heterocyclic radical, Heterocyclylalkyl, aryl sulfonyl and aromatic yl sodium sulfonamido;

    And described compound medicine is learned upward acceptable salt.

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