Human liver progenitors

Human liver progenitors

  • CN 1,351,656 B
  • Filed: 01/19/2000
  • Issued: 02/29/2012
  • Est. Priority Date: 01/19/1999
  • Status: Active Grant
First Claim
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1. one kind the compsn that comprises the cell mixture that takes out from human liver organization handled to obtain the method for said composition, wherein said mixture comprises the enriched populations of human liver progenitor, and this method comprises:

  • (a) be provided as the single celled suspension-s of human liver organization, described hepatic tissue contains the mixtures of the different big minicells that comprise prematurity and mature cell;

    And(b) keep simultaneously under the condition of diameter less than 15 microns immature cell removing mature cell, dwindle the volume of suspension-s,(c) suspension-s to reduced volume comprises the positive immunoselection that those cells of CD14, CD34, CD38, CD117, ICAM or its combination are expressed in selection;

    And/or comprise the negative immunoselection of those cells of remove expressing CD45, glycophorin A, connection protein 32 or its combinationSo that the cell mixture that comprises the human liver progenitor enriched populations to be provided, it is expressed ALPHA-FP or white protein or the two and all expresses.

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