Modified chimeric polyeptides with improved pharmacokinetic properties

Modified chimeric polyeptides with improved pharmacokinetic properties

  • CN 1,369,009 A
  • Filed: 05/23/2000
  • Published: 09/11/2002
  • Est. Priority Date: 06/08/1999
  • Status: Abandoned Application
First Claim
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1. coding can be in conjunction with a kind of isolated nucleic acid molecule of fusion polypeptide of VEGF polypeptide, and it comprises(a) nucleotide sequence of coding vegf receptor composition, this sequence is operably connected to(b) nucleotides sequence of a kind of poly composition of coding lists, wherein, described vegf receptor composition is unique vegf receptor composition of this fusion polypeptide, and, wherein, nucleotide sequence (a) mainly comprises the nucleotide sequence of aminoacid sequence of Ig structural domain 3 of the ectodomain of the nucleotide sequence of aminoacid sequence of Ig structural domain 2 of ectodomain of the first kind of vegf receptor of encoding and second kind of vegf receptor of coding.

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