Phenoxy carboxylic acid compounds and compositions for delivering active agents

Phenoxy carboxylic acid compounds and compositions for delivering active agents

  • CN 1,384,814 A
  • Filed: 11/06/2000
  • Published: 12/11/2002
  • Est. Priority Date: 11/05/1999
  • Status: Abandoned Application
First Claim
Patent Images

1. following formula:

  • compound and its salt;

    Wherein,R 1, R 2, R 3And R 4Each naturally H ,-OH, halogen, C 1-C 4Alkyl, C 2-C 4Alkenyl, C 1-C 4Alkoxyl group ,-C (O) R 8,-NO 2,-NR 9R 10Or-N +R 9R 10R 11(R 12) -R 5Be H ,-OH ,-NO 2, halogen ,-CF 3,-NR 14R 15,-N +R 14R 15R 16(R 13) -, acid amides, C 1-C 12Alkoxyl group, C 1-C 12Alkyl, C 2-C 12Alkenyl, carbamate, carbonic ether, urea or-C (O) R 18R 5Optional by halogen ,-OH ,-SH or-COOH replaces;

    R 5In optional insert O, N, S or-C (O)-;

    R 6Be C 1-C 12Alkylidene group, C 2-C 12Alkenylene or arylidene;

    R 6Optional by C 1-C 4Alkyl, C 2-C 4Alkenyl, C 1-C 4Alkoxyl group ,-OH ,-SH, halogen ,-NH 2Or-CO 2R 8Replace;

    R 6In optional O or the N of inserting;

    R 7Be key or arylidene;

    R 7Optional quilt-OH, halogen, C (O) CH 3, ,-NR 10R 11Or-N +R 10R 11R 12(R 13) -Replace;

    R 8Be H, C 1-C 4Alkyl, C 2-C 4Alkenyl or-NH 2R 9, R 10, R 11And R 12Be H or C independently 1-C 10Alkyl;

    R 13Be halogen ion, hydroxide ion, sulfate ion, tetrafluoroborate or phosphate radical;

    With R 14, R 15And R 16Be H, C independently 1-C 10The C that alkyl, quilt-COOH replace 1-C 10Alkyl, C 2-C 12The C that alkenyl, quilt-COOH replace 2-C 12Alkenyl or-C (O) R 17R 17Be-OH, C 1-C 10Alkyl or C 2-C 12Alkenyl;

    With R 18Be H, C 1-C 6Alkyl ,-OH ,-NR 14R 15Or N +R 14R 15R 16(R 13) -, its precondition is Work as R 1, R 2, R 3, R 4And R 5Be H and R 7When being key, R then 6Not C 1-C 6, C 9Or C 10Alkyl;

    Work as R 1, R 2, R 3And R 4Be H, R 5Be-OH and R 7When being key, R then 6Not C 1-C 3Alkyl;

    As R at least 1, R 2, R 3And R 4One of be not H, R 5Be-OH and R 7When being key, R then 6Not C 1-C 4Alkyl;

    Work as R 1, R 2And R 3Be H, R 4Be-OCH 3, R 5Be-C (O) CH 3And R 6When being key, R then 7Not C 3Alkyl;

    With Work as R 1, R 2, R 4And R 5Be H, R 3Be-OH and R 7When being key, R then 6It or not methyl.

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