Phosphonate compounds

Phosphonate compounds

  • CN 1,414,854 A
  • Filed: 12/04/2000
  • Published: 04/30/2003
  • Est. Priority Date: 12/03/1999
  • Status: Active Grant
First Claim
Patent Images

1. the phosphonate compound that has following structure:

  • Wherein;

    R 1And R 1'"'"' be independently-H, selectivity replaces-O (C 1-C 24) alkyl ,-O (C 1-C 24) alkenyl ,-O (C 1-C 24) acyl group ,-S (C 1-C 24) alkyl ,-S (C 1-C 24) alkenyl or-S (C 1-C 24) acyl group, wherein, R at least 1And R 1'"'"' in one be not-H that and wherein said alkenyl or acyl group can select to have 1-6 two keys;

    R 2And R 2'"'"' be independently-H, selectivity replaces-O (C 1-C 7) alkyl ,-O (C 1-C 7) alkenyl ,-S (C 1-C 7) alkyl ,-S (C 1-C 7) alkenyl ,-O (C 1-C 7) acyl group ,-S (C 1-C 7) acyl group ,-N (C 1-C 7) acyl group ,-NH (C 1-C 7) alkyl ,-N ((C 1-C 7) alkyl) 2, oxo, halogen ,-NH 2,-OH or-SH;

    R 3For with selectable connexon L on functional group or C α

    Go up the phosphate derivatives of the pharmaceutically active compound of available oxygen atom connection;

    X, when existing, for;

    L is valence link or formula-J-(CR 2) tThe difunctional link molecule of-G-, wherein, t is the integer of 1-24, J and G be independently-O-,-S-,-C (O) O-or-NH-, and R is-H, replacement or unsubstituted alkyl or alkenyl;

    M is the integer of 0-6;

    And n is 0 or 1.

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