Preparation of injectable suspensions having improved injectabity

Preparation of injectable suspensions having improved injectabity

CN
  • CN 1,430,501 A
  • Filed: 04/19/2001
  • Published: 07/16/2003
  • Est. Priority Date: 05/25/2000
  • Status: Active Application
First Claim
Patent Images

1. one kind is suitable for being expelled to the intravital compositions of host by pin, and said composition comprises:

  • The microgranule that comprises polymeric binder, said microgranule has the mass median diameter at least about 10 μ

    m;

    WithThe aqueous injectable excipient, wherein said microgranule is suspended in the concentration that is higher than about 30mg/ml and forms a kind of suspension in the said excipient, wherein the liquid phase of said suspension has the viscosity of 20cp at least under 20 ℃

    , and wherein said excipient is not the aqueous excipient that the excipient of water is formed by 3% volumetrical sodium carboxymethyl cellulose, 1% volumetrical polysorbate20,0.9% volumetrical sodium chloride and residue percentage ratio volume.

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