Substituted phthalides as anti-convulsive drugs

Substituted phthalides as anti-convulsive drugs

  • CN 1,440,398 A
  • Filed: 06/27/2001
  • Published: 09/03/2003
  • Est. Priority Date: 06/28/2000
  • Status: Active Application
First Claim
Patent Images

1. Formula (I) compound, its enantiomorph and diastereomer and with the additive salt of pharmaceutically acceptable acid or alkali:

  • Wherein;

    R 1Represent straight or branched (C 1-C 12) alkyl or urea groups, R 2Represent hydrogen atom or straight or branched (C 1-C 12) alkyl, perhaps R 1And R 2Form the cycloalkyl that contains 5 or 6 carbon atoms, R with the carbon atom that carries them 3Represent group CN, NO 2, NR aR '"'"' a, NR aSO 2R '"'"' a, NR aCZR 5Or CZNR aR '"'"' a, wherein Z represents oxygen or sulphur atom, and R 5Represent group OR a, R aOr NR aR '"'"' a(R wherein aAnd R '"'"' aCan be identical or different, and represent hydrogen atom or straight or branched (C 1-C 6) alkyl, (C 3-C 8) cycloalkyl, wherein moieties is straight or branched (C 3-C 8) cycloalkyl-(C 1-C 6) alkyl, phenyl or wherein moieties be the phenyl-(C of straight or branched 1-C 6) alkyl), R 4Represent hydrogen atom or radicals R as defined above 3, be to be understood that ;

    -phenyl or phenylalkyl can be on phenyl ring be selected from following substituting group and replace by one or more;

    straight or branched (C 1-C 6) alkyl, hydroxyl, straight or branched (C 1-C 6) alkoxyl group, amino, straight or branched (C 1-C 6) alkylamino, wherein each moieties is two of straight or branched-(C 1-C 6) alkylamino, NO 2And halogen atom, -alkyl can be by one or more hydroxyl, carboxyl, straight or branched (C of being selected from 1-C 6) alkyl, straight or branched (C 1-C 6) substituting group of alkoxyl group and halogen atom replaces, -cycloalkyl and cycloalkylalkyl can be by one or more hydroxyl, carboxyl, straight or branched (C of being selected from circular part 1-C 6) substituting group of alkoxyl group and halogen atom replaces, Its condition be formula (I) compound can not for the 3-methyl-, the 3-ethyl-, 3, the 3-dimethyl-or 3,3-diethyl--6-nitro-2-benzo [c] furanone or 3-methyl-or 3,3-dimethyl--6-amino-2-benzo [c] furanone or 3,3-dimethyl-6-(dimethylamino)-2-benzo [c] furanone.

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