Modified forms of pharmacologically active agents and uses therefor

Modified forms of pharmacologically active agents and uses therefor

  • CN 1,441,770 B
  • Filed: 06/19/2001
  • Issued: 03/21/2012
  • Est. Priority Date: 06/23/2000
  • Status: Active Grant
First Claim
Patent Images

1. compound with following structure:

  • X-L-ZWherein;

    X is the non-steroidal anti-inflammatory medicine, is selected from diclofenac and Naproxen Base;

    L is a covalence key, and perhaps L has structure;

    W-R-Wherein;

    R is a covalence key;

    Or alkylidene group;

    The ring alkylidene group;

    Heterocyclic radical;

    Alkylidene oxide;

    Alkylene group;

    Arylidene;

    Alkarylene or arylmethylene alkyl;

    Each R that wherein is not covalent linkage is unsubstituted;

    Or use hydroxyl;

    Alkoxyl group;

    Sulfydryl;

    Naphthenic base;

    Substituted naphthenic base;

    Heterocyclic radical;

    Substituted heterocyclic radical;

    Aryl;

    Substituted aryl;

    Heteroaryl;

    Substituted heteroaryl;

    Aryloxy;

    Substituted aryloxy;

    Halogen;

    Trifluoromethyl;

    Cyanic acid;

    Nitro;

    Nitrone;

    Amino;

    Amido;

    C (O) H;

    Acyl group;

    The oxygen acyl group;

    Carboxyl;

    Carbamate;

    Alkylsulfonyl;

    One or more substituted in sulphonamide and the sulfurylW is ester or reverse ester;

    AndZ is a sulfur-bearing functional group;

    It is selected from sulfoxide, sulphonate, reverse sulphonate, sulphonamide, reverse sulphonamide, sulfone,-sulfinic acid ester or reverse-sulfinic acid ester, and wherein said sulfur-bearing functional group contains unsubstituted hydrocarbyl portion or with the one or more substituted hydrocarbyl portion in hydroxyl, alkoxyl group, sulfydryl, naphthenic base, substituted naphthenic base, heterocyclic radical, substituted heterocyclic radical, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryloxy, substituted aryloxy, halogen, trifluoromethyl, cyanic acid, nitro, nitrone, amino, amido, C (O) H, acyl group, oxygen acyl group, carboxyl, carbamate, alkylsulfonyl, sulphonamide and the sulfuryl.

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