Bicyclo-pyrazoles active as kinase inhibitors,process for their prepn. and pharmaceutical compsns. comprising them

Bicyclo-pyrazoles active as kinase inhibitors,process for their prepn. and pharmaceutical compsns. comprising them

  • CN 1,447,810 A
  • Filed: 07/25/2001
  • Published: 10/08/2003
  • Est. Priority Date: 08/10/2000
  • Status: Active Application
First Claim
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1. the bicyclic pyrazole compounds and the pharmacologically acceptable salt thereof of formula (I):

  • WhereinR and R 1Identical or different, independently for hydrogen atom or be selected from following optional substituted group;

    R '"'"' ,-COR '"'"' ,-COOR '"'"' ,-CONHR '"'"' ,-CONR '"'"' R " ,-NH-C (=NH) NHR '"'"' ,-C (=NH) NHR '"'"' ,-SO 2R '"'"' ,-SO 2NHR '"'"' or-SO 2NR '"'"' R ";

    Wherein R '"'"' and R " identical or different, be independently selected from hydrogen or optional further substituted straight or branched C 1-C 6Alkyl, aryl, C 3-C 6Cycloalkyl or aryl C 1-C 6Alkyl, perhaps R '"'"' and R " form C together 4-C 6Alkylidene chain;

    Ra, Rb, Rc and Rd are identical or different, are independently selected from hydrogen, optional further substituted straight or branched C 1-C 6Alkyl, aryl, aryl C 1-C 6Alkyl or-CH 2OR '"'"' group, wherein R '"'"' is as above definition, and perhaps Ra and Rb and/or Rc and Rd form optional substituted C with its bonded carbon atom 3-C 6Cycloalkyl;

    M and n represent 0 or the integer of 1-2 independently of one another, and condition is that m+n is less than or equal to 2 (m+n≤

    2).

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